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PITTETD 檢索結果共 4141 筆,本頁資料從第 121 筆到第 132 筆

There are many reasons why managers are interested in maintaining control over their firm. Some potential reasons include compensation, autonomy, power, perquisites, and the ability to determine the terms under which the firm is acquired. This study examines one event that provides an opportunity for managers to take actions designed to maintain control of firm, the ini....

By Thomas J. Boulton-Business Administration-University of Pittsburgh-doctoral-2007-01-12
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The purpose of this study was to determine the point at which a minimally complex well-trained nonspeech task transfers to other nonspeech tasks of varying complexity. Participants included ten normal adult speakers. The nonspeech training task included bilabial production of a single intraoral pressure peak at either 7 or 15 cm H2O. Participants received random trainin....

By Julie B Kotler-Communication Science and Disorders-University of Pittsburgh-masters-2007-01-05
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Antiretroviral drug treatments and vaccine strategies are hampered by the ability of the HIV to generate variants able to evade their protective effects. Understanding the effects of these interventions on virus evolution could aid in the design of targeted antiviral strategies. We addressed this in a cohort of SIV infected non-human primates given short-term antiviral ....

By Rachel Taber-Molecular Virology and Microbiology-University of Pittsburgh-doctoral-2007-01-05
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The pXO1 and pXO2 plasmids of B. anthracis are both necessary for full virulence, and understanding the mechanisms by which these plasmids replicate would be helpful in combating anthrax and the spread or use of these plasmids in other systems. A 5-kilobase region of the pXO1 plasmid was cloned into an E. coli vector and replicates when introduced into B. anthracis. Del....

By Eowyn May Tinsley-Molecular Virology and Microbiology-University of Pittsburgh-doctoral-2006-12-20
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The Practice of Coercive Diplomacy in the Post-9/11 Period The model of coercive diplomacy has been used as a framework for analyzing various cases of confrontation between two or more states. Coercive diplomacy is the use by a state of the threat of force to achieve its demands. Formulated by Alexander L. George, this model has been applied on a diverse group of case s....

By Sharad Joshi-Public and International Affairs-University of Pittsburgh-doctoral-2006-12-20
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This dissertation examines influence and decision-making within the transatlantic security regime, focusing on the four major member states of NATO. Two cases of post-Cold War transatlantic military intervention are examined in which regime member states sought to develop and adopt a single, collective policy on the use of military force outside of NATOs traditional (i....

By Mark Wintz-Public and International Affairs-University of Pittsburgh-doctoral-2006-12-15
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Disruption in important cell survival signaling pathways may represent a central mechanism in neurodegenerative disease processes. 6-Hydroxydopamine (6-OHDA) is an oxidative neurotoxin that is commonly used to injure catecholaminergic cells of the central and peripheral nervous systems, and has been used extensively to model Parkinsons Disease. Although it has been docu....

By Elisabeth Mole Chalovich-Cellular and Molecular Pathology-University of Pittsburgh-doctoral-2006-12-14
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Caveolin-1 (cav-1) has been reported to regulate apoptosis, lipid metabolism and endocytosis. In the present study, we demonstrate that cav-1 can act as a potent immunomodulatory molecule in murine macrophages and play an important role in the development of fibrosis. In murine alveolar and peritoneal macrophages, loss of function experiments using siRNA showed that dow....

By xiaomei wang-Cellular and Molecular Pathology-University of Pittsburgh-doctoral-2006-12-13
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Extensive genetic variability at particular loci is observed among many bacteria because alleles confer higher fitness advantages under certain situations. Extensive diversity is observed at the Salmonella rfb locus, encoding enzymes responsible for synthesis of the O-antigen polysaccharide. Historically, diversity at the rfb locus was thought to be caused by selective ....

By Hans K Wildschutte-Molecular Virology and Microbiology-University of Pittsburgh-doctoral-2006-12-13
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Parkinsons disease (PD) is a progressive neurodegenerative disorder resulting in part from loss of nigrostriatal dopamine (DA) neurons. Treatments act only to relieve symptoms. It is therefore essential to develop treatments that slow or reverse the neurodegenerative process. Here, I explored exercise as a potential treatment against a 6-hydroxydopamine (6-OHDA) rat mod....

By Annie D Cohen-Neurobiology-University of Pittsburgh-doctoral-2006-12-11
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Deficiency of DNA repair has been shown to lead to cancer in multiple human disease states. We therefore hypothesized that deficiency of Nucleotide Excision Repair is involved in the etiology of breast cancer. This work was carried out using a novel in vitro culture system for both normal and cancerous breast tissue developed in the Latimer laboratory. Primary cultures ....

By Jennifer Maria Johnson-Biochemistry and Molecular Genetics-University of Pittsburgh-doctoral-2006-12-01
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Herpes Simplex Virus-1 (HSV-1) infection has been shown to be very resistant to the effects of the cellular interferon response. However, in the absence of viral gene expression HSV-1 induces the expression of cellular interferon-stimulated genes, possibly through activation of the interferon-regulatory factor 3 (IRF-3) cascade. The induction of IRF-3 by HSV-1 infection....

By Kasey Michelle Eidson-Molecular Virology and Microbiology-University of Pittsburgh-doctoral-2006-11-30
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