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dspace.mit.edu 檢索結果共 84617 筆,本頁資料從第 181 筆到第 192 筆

The majority of disease-associated variants lie outside protein-coding regions, suggesting a link between variation in regulatory regions and disease predisposition. We studied differences in chromatin states using five histone modifications, cohesin, and CTCF in lymphoblastoid lines from 19 individuals of diverse ancestry. We found extensive signal variation in regulat....

By Maya Kasowski,Sofia Kyriazopoulou-Panagiotopoulou,Fabian Grubert,Judith B. Zau--American Association for the Advancement of Science (AAAS)--2016-01-06
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Although only 5% of the human genome is conserved across mammals, a substantially larger portion is biochemically active, raising the question of whether the additional elements evolve neutrally or confer a lineage-specific fitness advantage. To address this question, we integrate human variation information from the 1000 Genomes Project and activity data from the ENCOD....

By Lucas D. Ward,Manolis Kellis--American Association for the Advancement of Science (AAAS)--2016-01-06
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Genome function is dynamically regulated in part by chromatin, which consists of the histones, non-histone proteins and RNA molecules that package DNA. Studies in Caenorhabditis elegans and Drosophila melanogaster have contributed substantially to our understanding of molecular mechanisms of genome function in humans, and have revealed conservation of chromatin componen....

By Anshul Kundaje,Nischay Kumar,Manolis Kellis,Daniel S. Day--American Association for the Advancement of Science (AAAS)--2016-01-06
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Alzheimer’s disease (AD) is a severe age-related neurodegenerative disorder characterized by accumulation of amyloid-β plaques and neurofibrillary tangles, synaptic and neuronal loss, and cognitive decline. Several genes have been implicated in AD, but chromatin state alterations during neurodegeneration remain uncharacterized. Here we profile transcriptional and chr....

By Elizabeta Gjoneska,Andreas R. Pfenning,Hansruedi Mathys,Gerald Quon,Anshul Kundaje,Li-Hu Tsai--American Association for the Advancement of Science (AAAS)--2016-01-06
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The per-event yield of the highest transverse momentum charged particle and charged-particle jet, integrated above a given p[min over T] threshold starting at p[min over T] = 0.8 and 1 GeV, respectively, is studied in pp collisions at √s = 8  TeV. The particles and the jets are measured in the pseudorapidity ranges |η| < 2.4 and 1.9, respectively. The data are s....

By V. Khachatryan,A. M. Sirunyan,A. Tumasyan,W. Adam,T. Bergauer,M. Dragic--American Physical Society--2016-01-05
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The lack of assessment tools to analyze serious games and insufficient knowledge on their impact on players is a recurring critique in the field of game and media studies, education science and psychology. Although initial empirical studies on serious games usage deliver discussable results, numerous questions remain unacknowledged. In particular, questions regarding th....

By Konstantin Mitgutsch,Narda Alvarado--Association for Computing Machinery (ACM)--2016-01-05
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The power of failures and irritations for learning and experiencing is known since ancient times. Like Ulysses, the hero of Homer's epic poem the Odyssey, the protagonist learns through experiencing obstacles and suffering through unexpected actions.....

By Konstantin Mitgutsch--Singapore-MIT GAMBIT Game Lab--2016-01-05
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The problem of optimal planning under uncertainty in collaborative multi-agent domains is known to be deeply intractable but still demands a solution. This thesis will explore principled approximation methods that yield tractable approaches to planning for AI assistants, which allow them to understand the intentions of humans and help them achieve their goals. AI assist....

By Owen Macindoe--Association for the Advancement of Artificial Intelligence--2016-01-05
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We present POMCoP, a system for online planning in collaborative domains that reasons about how its actions will affect its understanding of human intentions, and demonstrate its use in building sidekicks for cooperative games. POMCoP plans in belief space. It explicitly represents its uncertainty about the intentions of its human ally, and plans actions which reveal th....

By Owen Macindoe,Leslie P. Kaelbling,Tomas Lozano-Perez--Association for the Advancement of Artificial Intelligence--2016-01-05
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Background. Although many risk factors are well known, Clostridium difficile infection (CDI) continues to be a significant problem throughout the world. The purpose of this study was to develop and validate a data-driven, hospital-specific risk stratification procedure for estimating the probability that an inpatient will test positive for C difficile. Methods. We c....

By Jenna Wiens,Wayne N. Campbell,Ella S. Franklin,John V. Guttag,Eric Horvitz--Oxford University Press--2016-01-05
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Background Viruses can evade immune surveillance, but the underlying mechanisms are insufficiently understood. Here, we sought to understand the mechanisms by which natural killer (NK) cells recognize HIV-1-infected cells and how this virus can evade NK-cell-mediated immune pressure. Methods and Findings Two sequence mutations in p24 Gag associated with the presence of ....

By Christina F. Thobakgale,Camilo A. Jimenez Cruz,Wilfredo F. Garcia-Beltran,Jonathan M. Carlson,Nie van--Public Library of Science--2016-01-05
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Iron deficiency anemia (IDA) affects > 500 million people worldwide, and is linked to impaired cognitive development and function in children. Helicobacter pylori, a class 1 carcinogen, infects about half of the world’s population, thus creating a high likelihood of overlapping risk. This study determined the effect of H. pylori infection on iron homeostasis in INS-GA....

By Monika Burns,Sureshkumar Muthupalani,Zhongming Ge,Timothy C. Wang,Catriona Cunningham,K Ennis--Public Library of Science--2016-01-05
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