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dspace.mit.edu 檢索結果共 84617 筆,本頁資料從第 205 筆到第 216 筆

We reconstructed oxygenation changes in the upwelling ecosystem off Concepcion (36° S), Chile, using inorganic and organic proxies in a sediment core covering the last ca. 110 years of sedimentation in this area. Authigenic enrichments of Mo, U and Cd were observed between ca. 1935 and 1971 CE, implying a prolonged period with predominantly more reduced conditions in b....

By B. Srain,S. Pantoja,C. B. Lange,J. McKay,M. Salamanca,Julio Sepulveda,P. Muno--Copernicus GmbH--2016-01-04
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Although estimation of turbulent transport parameters using inverse methods is not new, there is little evaluation of the method in the literature. Here, it is shown that extended observation of the broad-scale hydrography by Argo provides a path to improved estimates of regional turbulent transport rates. Results from a 20-year ocean state estimate produced with the EC....

By D. Ferreira,Gael Forget,Xinfeng Liang--Copernicus GmbH--2016-01-04
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Investigation of neural representation of movement planning has attracted the attention of neuroscientists, as it may reveal the sensorimotor transformation essential to motor control. The analysis of muscle synergies based on the activity of agonist–antagonist (AA) muscle pairs may provide insight into such transformations, especially for a reference frame in the mus....

By Hiroaki Hirai,Fumio Miyazaki,Hiroaki Naritomi,Keitaro Koba,Takanori Oku,Kanna Uno,Mitsu Uemura--Frontiers Research Foundation--2016-01-04
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Many common voice disorders are chronic or recurring conditions that are likely to result from inefficient and/or abusive patterns of vocal behavior, referred to as vocal hyperfunction. The clinical management of hyperfunctional voice disorders would be greatly enhanced by the ability to monitor and quantify detrimental vocal behaviors during an individual’s activitie....

By Daryush D. Mehta,Jarrad H. Van Stan,Marzyeh Ghassemi,John V. Guttag,Harold A. Cheyne,Rob Hillman--Frontiers Research Foundation--2016-01-04
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Several regions of the human brain respond more strongly to faces than to other visual stimuli, such as regions in the amygdala (AMG), superior temporal sulcus (STS), and the fusiform face area (FFA). It is unclear if these brain regions are similar in representing the configuration or natural appearance of face parts. We used functional magnetic resonance imaging of he....

By Golijeh Golarai,Dara G. Ghahremani,Jennifer L. Eberhardt,John D. E. Gabrieli--Frontiers Research Foundation--2016-01-04
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Measuring resilience to natural hazards is a central issue in the hazard mitigation sciences. This paper applied a confirmatory factor methodology to operationalize the biophysical, built-environment, and socioeconomic resilience dimensions for local jurisdictions in large urban metropolitan areas in South Korea. Mapping the factor scores of the dimensions revealed grea....

By Jae Shim,Chun Il Kim--MDPI AG--2016-01-04
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People learn modality-independent, conceptual representations from modality-specific sensory signals. Here, we hypothesize that any system that accomplishes this feat will include three components: a representational language for characterizing modality-independent representations, a set of sensory-specific forward models for mapping from modality-independent representa....

By Goker Erdogan,Ilker Yildirim,Robert A. Jacobs--Public Library of Science--2016-01-04
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The dynamic behaviors of signaling pathways can provide clues to pathway mechanisms. In cancer cells, excessive phosphorylation and activation of the Akt pathway is responsible for cell survival advantages. In normal cells, serum stimulation causes brief peaks of extremely high Akt phosphorylation before reaching a moderate steady-state. Previous modeling assumed this p....

By Tri Hieu Nim,Le Luo,Jacob K. White,Lisa Tucker-Kellogg,Marie-Veronique Clement--Public Library of Science--2016-01-04
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The Piwi pathway is deeply conserved amongst animals because one of its essential functions is to repress transposons. However, many Piwi-interacting RNAs (piRNAs) do not base-pair to transposons and remain mysterious in their targeting function. The sheer number of piRNA cluster (piC) loci in animal genomes and infrequent piRNA sequence conservation also present challe....

By Gung-wei Chirn,Reazur Rahman,Yuliya A. Sytnikova,Jessica A. Matts,Mei Zeng,Daniel Gerlach,Mi Yu--Public Library of Science--2016-01-04
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Post-transcriptional modifications of transfer RNAs (tRNAs) have long been recognized to play crucial roles in regulating the rate and fidelity of translation. However, the extent to which they determine global protein production remains poorly understood. Here we use quantitative proteomics to show a direct link between wobble uridine 5-methoxycarbonylmethyl (mcm[super....

By Wenjun Deng,I. Ramesh Babu,Dan Su,Shanye Yin,Thomas J. Begley,Peter C. Dedon--Public Library of Science--2016-01-04
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The human mutation rate is an essential parameter for studying the evolution of our species, interpreting present-day genetic variation, and understanding the incidence of genetic disease. Nevertheless, our current estimates of the rate are uncertain. Most notably, recent approaches based on counting de novo mutations in family pedigrees have yielded significantly small....

By Mark Lipson,Po-Ru Loh,Sriram Sankararaman,Nick Patterson,Bonnie Berger,David Reich--Public Library of Science--2016-01-04
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Macrophages display flexible activation states that range between pro-inflammatory (classical activation) and anti-inflammatory (alternative activation). These macrophage polarization states contribute to a variety of organismal phenotypes such as tissue remodeling and susceptibility to infectious and inflammatory diseases. Several macrophage- or immune-related genes ha....

By Musa A. Hassan,Kirk D. Jensen,Vincent Butty,Kenneth Hu,Erwan Boedec,Pjotr Prins,Jeroen Saeij--Public Library of Science--2016-01-04
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