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dspace.mit.edu 檢索結果共 84617 筆,本頁資料從第 73 筆到第 84 筆

Many natural underwater adhesives harness hierarchically assembled amyloid nanostructures to achieve strong and robust interfacial adhesion under dynamic and turbulent environments. Despite recent advances, our understanding of the molecular design, self-assembly and structure–function relationships of these natural amyloid fibres remains limited. Thus, designing biom....

By Chao Zhong,Thomas Gurry,Allen A. Cheng,Jordan Downey,Zhengtao Deng,Collin M. Stultz,Tim Lu--Nature Publishing Group--2016-01-14
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There is an ever growing number of users with accounts on multiple social media and networking sites. Consequently, there is increasing interest in matching user accounts and profiles across different social networks in order to create aggregate profiles of users. In this paper, we present models for Digital Stylometry, which is a method for matching users through stylo....

By Soroush Vosoughi,Helen L. Zhou,Deb K. Roy--Springer-Verlag--2016-01-13
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Although hexagonal boron nitride (h-BN) is a good candidate for gate-insulating materials by minimizing interaction from substrate, further applications to electronic devices with available two-dimensional semiconductors continue to be limited by flake size. While monolayer h-BN has been synthesized on Pt and Cu foil using chemical vapour deposition (CVD), multilayer h-....

By Soo Min Kim,Allen Hsu,Min Ho Park,Sang Hoon Chae,Seok Joon Yun,Joo Song Lee--Nature Publishing Group--2016-01-13
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Self-consistent (non-)Abelian statistics in 2+1 dimensions (2+1D) are classified by modular tensor categories (MTCs). In recent works, a simplified axiomatic approach to MTCs, based on fusion coefficients N[ij over k] and spins s_{i}, was proposed. A numerical search based on these axioms led to a list of possible (non-)Abelian statistics, with rank up to N = 7. However....

By Kareljan Schoutens,Xiao-Gang Wen--American Physical Society--2016-01-13
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We present self-cloning CRISPR/Cas9 (scCRISPR), a technology that allows for CRISPR/Cas9-mediated genomic mutation and site-specific knockin transgene creation within several hours by circumventing the need to clone a site-specific single-guide RNA (sgRNA) or knockin homology construct for each target locus. We introduce a self-cleaving palindromic sgRNA plasmid and a s....

By Mandana Arbab,Sharanya Srinivasan,Niels Geijsen,Richard I. Sherwood,Tatsunori Benjam Hashimoto--Elsevier--2016-01-13
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As a group, we met to discuss the current challenges for creating meaningful patient-specific in vitro models to study brain disorders. Although the convergence of findings between laboratories and patient cohorts provided us confidence and optimism that hiPSC-based platforms will inform future drug discovery efforts, a number of critical technical challenges remain. Th....

By Kristen J. Brennand,M. Carol Marchetto,Nissim Benvenisty,Allison Ebert,Juan Carlos Izpisua Belmon--Elsevier--2016-01-13
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Hundreds of transcription factors (TFs) are expressed in each cell type, but cell identity can be induced through the activity of just a small number of core TFs. Systematic identification of these core TFs for a wide variety of cell types is currently lacking and would establish a foundation for understanding the transcriptional control of cell identity in development,....

By Ana C. D’Alessio,Zi Peng Fan,Katherine J. Wert,Petr Baranov,Malkiel A. Cohen,Janmee Saini--Elsevier--2016-01-13
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The quantitative analysis of cardiomyocyte function is essential for stem cell-based approaches for the in vitro study of human cardiac physiology and pathophysiology. We present a method to comprehensively assess the function of single human pluripotent stem cell-derived cardiomyocyte (hPSC-CMs) through simultaneous quantitative analysis of contraction kinetics, force ....

By Jan David Kijlstra,Dongjian Hu,Nikhil Mittal,Peter van der Meer,Arman Garakani,Ibrahim J. Domian,E Ka--Elsevier--2016-01-13
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Inhibition of Poly(ADP-ribose) Polymerase1 (PARP1) impairs DNA damage repair, and early generation PARP1/2 inhibitors (olaparib, niraparib, etc.) have demonstrated clinical proof of concept for cancer treatment. Here, we describe the development of the novel PARP inhibitor E7449, a potent PARP1/2 inhibitor that also inhibits PARP5a/5b, otherwise known as tankyrase1 and ....

By Paul Chang--Impact Journals/National Center for Biotechnology Information (U.S.)--2016-01-13
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Using new data from the K2 mission, we show that WASP-47, a previously known hot Jupiter host, also hosts two additional transiting planets: a Neptune-sized outer planet and a super-Earth inner companion. We measure planetary properties from the K2 light curve and detect transit timing variations (TTVs), confirming the planetary nature of the outer planet. We performed ....

By Juliette C. Becker,Andrew Vanderburg,Fred C. Adams,Saul A. Rappaport,Hans Martin Schwengeler--IOP Publishing--2016-01-13
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We analyzed the warm Spitzer/IRAC data of KIC 8462852. We found no evidence of infrared excess at 3.6 μm and a small excess of 0.43 ± 0.18 mJy at 4.5 μm below the 3σ threshold necessary to claim a detection. The lack of strong infrared excess 2 years after the events responsible for the unusual light curve observed by Kepler further disfavors the scenarios involving....

By Massimo Marengo,Alan Hulsebus,Sarah E. Willis--IOP Publishing--2016-01-13
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Knowledge of mechanical and physical property evolution due to irradiation damage is essential for the development of future fission and fusion reactors. Ion-irradiation provides an excellent proxy for studying irradiation damage, allowing high damage doses without sample activation. Limited ion-penetration-depth means that only few-micron-thick damaged layers are produ....

By F. Hofmann,D. R. Mason,S. L. Dudarev,Jeffrey K. Eliason,Alexei Maznev,Keith Adam Nelson--Nature Publishing Group--2016-01-13
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