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Controlled Flow Cavitation Technology For Use In Pharmaceutical Processing Applications And Its Commercialization Plan.

作者:Chien-Chih Chen,
畢業學校:Case Western Reserve University
出版單位:Case Western Reserve University / OhioLINK
核准日期:2012-08-24
類型:Electronic Thesis or Dissertation
權限:restricted; full text unavailable until 2014-08-17.This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable cop....

英文摘要

Many new drugs fail to pass clinical trials every year because of poor bioavailability. More than 40% of those New Chemical Entities fail to reach commercialization due to poor solubility. Nanotechnology, which can increase the active surface area, often is employed to improve the solubility of drugs. However, existing technologies using top-down approaches such as grinding, milling, and homogenization have issues of inconsistent particle size distribution, batch contamination, scalability, and high maintenance costs. There is a need to develop a bottom-up nanotechnology approach. This thesis focuses on the development and commercialization of GenSyn’s particle engineering capabilities using in-house Controlled Flow Cavitation (CFC™) Technology for its use in pharmaceutical processing. Based on the initial results, the commercialization of GenSyn’s particle engineering capabilities is considered feasible.


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