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牛蒡複方微米精華液輔助幽門螺旋桿菌感染之胃潰瘍患者之治療效果評估

Effectiveness of great burdock essence compounds in the adjuvant treatment of gastric ulcer patients infected with Helicobacter pylori

作者:劉雪嬌
畢業學校:輔英科技大學
出版單位:輔英科技大學
核准日期:2013-01-31
類型:Electronic Thesis or Dissertation
權限:Copyright information available at source archive--Fooyin University....

中文摘要

幽門螺旋桿菌 (Helicobacter pylori) 為革蘭氏陰性桿菌,是導致胃潰瘍及胃癌的重要危險因子之一。而牛蒡則是一種具有保護胃腸道粘膜組織,減少幽門螺桿菌對胃部組織造成損害的天然植物。本研究所使用的牛蒡複方微米精華液主要含有牛蒡 (Arctium lappa, Linn) 、新疆紫草 (Arnebia euchroma) 及當歸 (Angelica sinensis) 等成分。主要的研究目的為評估牛蒡複方微米精華液對於存在幽門螺旋桿菌的潰瘍病患,臨床上的輔助治療效果。本研究共收集五十五位具有幽門螺旋桿菌感染之胃潰瘍患者,分為兩組,其中實驗組共二十八人,服用牛蒡複方微米精華液;對照組共有二十七人,服用安慰劑。受試者依照傳統治療方式服用抗生素治療一週後,隨機給與受試患者牛蒡複方精華液或安慰劑,服用方法為每天早晚餐飯後口服使用一瓶 (一瓶含10 mL) ,連續服用四週後,再以碳13尿素呼氣試驗 (13C Urea breath test ) 評估幽門桿菌存在之情況。研究結果顯示,服用牛蒡複方微米精華液四週後之實驗組,在碳13尿素呼氣試驗結果,陰性有二十六人,陽性二人;反之,服用安慰劑之對照組則十九人呈陰性,八人呈陽性。服用牛蒡複方微米精華液之病患,碳13尿素呼氣試驗結果陽性者明顯低於對照組 (p= 0.04) ,顯示牛蒡複方微米精華液確實具有輔助抑制幽門螺旋桿菌的功效。

英文摘要

Helicobacter pylori is a gram negative bacilli, and one of the important risk-factors of gastric ulcer and gastric cancer. Studies have found that burdock can protect gastrointestinal mucosa that can reduce the tissue damage of stomach from H pylori. In present study, the Great burdock essence compounds which contains Arctium lappa Linn, Arnebia euchroma, and Angelica sinensis. The aims of present study was to assess the effectiveness of the great burdock essence compounds in the adjuvant treatment of H. pylori infection in clinical practice.. Fifty-five patients infected by H. pylori infection and had gastric ulcer were included into the study., twenty-eight subjects were randomly selected to take great burdock essence compounds and 27 subjects took placebo for a month after regular antibiotics treatment for a week. The 13C-Urea Breath Test was use to investigate the H. pylori present. The results showed that only 2 patients were positive among 28 subjects in the experimental group comparing to 8 positive patient among 27 subjects in control group (p = 0.04). The result shows that the great burdock essence is effective in the adjuvant treatment of H. pylori infection.


指導教授 - 林綉茹 教授

指導教授 - 林清江 助理教授

委員 - 陳福安教授

召集委員 - 鄭添祿


 

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